Tumor-Microenvironment-Induced Degradation of Ultrathin Gadolinium Oxide Nanoscrolls for Magnetic-Resonance-Imaging-Monitored, Activatable Cancer Chemotherapy

The development of biodegradable inorganic nanoparticles with a tumor microenvironment-activated therapeutic mode of action is urgently needed for precision cancer medicine. Herein, the synthesis of ultrathin lanthanide nanoscrolls (Gd2O3 NSs) is reported, which biodegrade upon encountering the tumor microenvironment. The Gd2O3 NSs showed highly controlled magnetic properties, which enabled their high-resolution magnetic resonance imaging (MRI). Importantly, Gd2O3 NSs degrade in a pH-responsive manner and selectively penetrate tumor tissue, enabling the targeted release of anti-cancer drugs. Gd2O3 NSs can be efficiently loaded with an anti-cancer drug (DOX, 80%) and significantly inhibit tumor growth with negligible cellular and tissue toxicity both invitro and invivo. This study may provide a novel strategy to design tumor microenvironment-responsive inorganic nanomaterials for biocompatible bioimaging and biodegradation-enhanced cancer therapy.