4.8 Article

Vinylogous Reactivity of Cyclic 2-Enones: Organocatalysed Asymmetric Addition to 2-Enals to Synthesize Fused Carbocycles

Journal

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 20, Pages 6742-6746

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201901902

Keywords

[3+3]-annulations; bicyclo[4,4,0]decanes; bicyclo[4,3,0]nonanes; organocatalysis; vinylogous reactivity

Funding

  1. European Research Council under the European Union [277588]
  2. Greek General Secretariat of Research and Technology for matching (reward) funds [KA: 4143]
  3. Alexander S. Onassis Public Benefit Foundation [G ZM 063-1/2016-2017]

Ask authors/readers for more resources

A method for asymmetric and site selective annulations at the and positions of cyclic 2-enones with ,-unsaturated aldehydes has been developed. The organocatalysed [3+3]-annulations proceed with high levels of regio-, diastereo-, and enantioselectivity, affording a series of high value fused carbocycles. Further elaboration gave key lactones (both bridged and fused).

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available