Journal
ANALYTICAL CHEMISTRY
Volume 91, Issue 6, Pages 4172-4178Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.9b00224
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Funding
- National Natural Science Foundation of China [21203138]
- Natural Science Foundation of Tianjin [17JCYBJC19600]
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT (CRI) [2018R1A3B1052702]
- Basic Science Research Program - Ministry of Education [2017R1D1A1B03032561, 2017R1D1A1B03030062]
- Korea Research Fellowship Program - Ministry of Science and ICT through the National Research Foundation of Korea [2016H1D3A1938052]
- National Research Foundation of Korea [2016H1D3A1938052] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A high brightness red fluorescent probe (S-BODIPY) has been developed for the sensitive and specific imaging of HClO/ClO- in vitro and in vivo. This probe exhibits some distinctive features such as excellent resistance to photobleaching, a high fluorescence brightness, high selectivity, as well as a good biocompatibility. Upon oxidation of the thioether group into sulfoxide, the probe showed a noticeable ratiometric fluorescence response toward ClO- with fast response (within 30 s) and a low detection limit (59 nM). The probe demonstrated the successful imaging of exogenous and endogenous HClO/ClO- in living HeLa cells, zebrafish, and mice with high signal-to-noise ratios. S-BODIPY allows for the real-time monitoring the level of ClO- in living cells by ratiometric fluorescence imaging, opening up exciting prospects to brightness and good photostability for in vivo imaging. develop red and even near-infrared BODIPYs with high
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