Journal
ANALYTICAL CHEMISTRY
Volume 91, Issue 5, Pages 3215-3220Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.8b03114
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Funding
- National Natural Science Foundation of China [21520102007]
- Department of Science and Technology of Jiangxi Province [20165BCB19013]
- Program for Changjiang Scholars and Innovative Research Team in Universities (PCSIRT) [IRT_17R20]
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Supercharged protein ions produced by electrospray ionization are extremely efficient proton donors for secondary ionization. Here, by electrospraying the protein solutions containing 5% 1,2-butylene carbonate, the supercharged protein ions with unusually high proton density were produced as the primary ions for the ionization of exhaled breath samples in the extractive electrospray ionization mass spectrometry (EESI-MS), which resulted in the enhanced ionization efficiency for the breath analytes even with relatively low gas phase basicity. Moreover, the total number of metabolites detected in breath increased by about 260% in the mass range of 200-500 Da, owing to the substantial signal enhancement for breath metabolites, providing complementary and additional information to conventional SESI.
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