Journal
ANALYTICA CHIMICA ACTA
Volume 1049, Issue -, Pages 74-81Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2018.10.022
Keywords
Electroactive MOFs; Ligand design; Electrochemical aptasensor
Categories
Funding
- National Natural Science Foundation of China [21473135, 21673180, 21605121, 21727805]
- 59th China Postdoctoral Science Foundation [2016M590966]
- Young Talent fund of University Association for Science and Technology in Shaanxi, China [20170705]
Ask authors/readers for more resources
Electroactive metal-organic frameworks (MOFs) with large surface area and manipulatable structural properties show promise as a new type of signal probe for electrochemical biosensing application. In this work, an electroactive Ni-MOF, assembled by the redox-active ligands 4,4',4 ''-Tricarboxytriphenylamine (H(3)TCA), a triphenylamine derivatives, as the electroactive source and magnetic ordered Ni4O4 clusters as electronic transport nodes, is first designed and applied for electrochemical aptasensing of thrombin (Tb). The designed Ni-MOF probe realizes a stable and sensitive electrochemical signal output based on simple sandwich-type aptasensing because the high-content TCA active sites and good magnetic ordered intermediate of Ni4O4 clusters are periodically arranged in well-defined porous structure of the MOF. The Ni-MOF probe assembled by redox-active ligand presents the high stability and can be directly applied in electrochemical aptasensor, avoiding any post-modification and the addition of redox mediators. As a result, the constructed electrochemical aptasensor shows a wide linear relationship for Tb from 0.05 pM to 50 nM and a detection limit of 0.016 pM (S/N = 3). Furthermore, the proposed aptasensor is successfully applied to analysis of target Tb in real serum sample with satisfactory results. The present work indicates that fabricating a redox-active organic molecule in functionalized MOFs offer a feasible strategy to design high-stable electroactive MOFs for construction of electrochemical biosensors with simplicity, high selectivity and sensitivity. (C) 2018 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available