Journal
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
Volume 357, Issue 5, Pages 379-383Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjms.2019.02.009
Keywords
Idiopathic pulmonary fibrosis; Genetics; Medical; familial interstitial pneumonia
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Funding
- NHLBI NIH HHS [K23 HL138190, R01 HL130796] Funding Source: Medline
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Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease. IPF is a complex disease, with environmental and genetic factors variably contributing to disease susceptibility and outcomes. A host of common gene variants with modest effect size impart disease risk in patients with sporadic IPF, while rare variants with large effect size influence disease risk in those with familial interstitial pneumonia. In this review, we highlight several common and rare variants underpinning IPF risk and call attention to recently published studies informing our understanding of this risk.
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