Journal
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Volume 316, Issue 5, Pages L705-L719Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajplung.00492.2018
Keywords
arterial oxygen tension; club cell protein-16; e-cigarette; transcutaneous oxygen tension
Categories
Funding
- Fonds Erasme pour la Recherche Medicale, Belgium
- Fondation pour la Chirurgie Cardiaque, Belgium
- Fondation Emile Saucez-Rene Van Poucke, Belgium
- Prix Docteur & Mrs Rene Tagnon, Belgium
- Fondation IRIS, Belgium
- Prix de l'Association Andre Vesale, Belgium
- Fondation Drieghe-Miller, Belgium
- Astra Zeneca, Belgium
- Fonds Fruit de Deux Vies, Belgium
- Fond David and Alice Van Buuren, Belgium
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When heated by an electronic cigarette, propylene glycol and glycerol produce a nicotine-carryingaerosol. This hygroscopic/hyperosmolar aerosol can deposit deep within the lung. Whether these deposits trigger local inflammation and disturb pulmonary gas exchanges is not known. The aim of this study was to assess the acute effects of high-wattage electronic cigarette vaping with or without nicotine on lung inflammation biomarkers, transcutaneous gas tensions, and pulmonary function tests in young and healthy tobacco smokers. Acute effects of vaping without nicotine on arterial blood gas tensions were also assessed in heavy smokers suspected of coronary artery disease. Using a single-blind withinsubjects study design, 25 young tobacco smokers underwent three experimental sessions in random order: sham-vaping and vaping with and without nicotine at 60 W. Twenty heavy smokers were also exposed to sham-vaping (n = 10) or vaping without nicotine (n = 10) in an open-label, randomized parallel study. In the young tobacco smokers, compared with sham-vaping: 1) serum club cell protein-16 increased after vaping without nicotine (mean +/- SE, -0.5 +/- 0.2 vs. + 1.1 +/- 0.3 mu g/l, P = 0.013) and vaping with nicotine (+1.2 +- 0.3 mu g/l, P = 0.009); 2) transcutaneous oxygen tension decreased for 60 min after vaping without nicotine (nadir, -0.3 +/- 1 vs. -15.3 +/- 2.3 mmHg, P = 0.001) and for 80-min after vaping with nicotine (nadir, -19.6 +/- 2.8 mmHg, P = 0.001). Compared with sham vaping, vaping without nicotine decreased arterial oxygen tension for 5 min in heavy-smoking patients (+ 5.4 +/- 3.3 vs. - 5.4 +/- 1.9 mmHg, P = 0.012). Acute vaping of propylene glycol/glycerol aerosol at high wattage with or without nicotine induces airway epithelial injury and sustained decrement in transcutaneous oxygen tension in young to-bacco smokers. Intense vaping conditions also transiently impair arterial oxygen tension in heavy smokers.
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