Journal
AMERICAN JOURNAL OF PATHOLOGY
Volume 189, Issue 6, Pages 1145-1158Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajpath.2019.02.006
Keywords
-
Categories
Funding
- Queen Elizabeth II Graduate Scholarship in Science and Technology
- Princess Margaret Cancer Centre Research Foundation
- Canada Research Chair in Matrix Dynamics
- Canadian Institutes of Health Research [MOP36332]
Ask authors/readers for more resources
Monocyte lineage cells play important roles in health and disease. Their differentiation into macrophages is crucial for a broad array of immunologic processes that regulate inflammation, neoplasia, and infection. In certain pathologic conditions, such as foreign body reactions and peripheral inflammatory lesions, monocytes fuse to form large, multinucleated giant cells (MGCs). Currently, our knowledge of the fusion mechanisms of monocytes and the regulation of MGC formation and function in discrete pathologies is limited. Herein, we consider the types and function of MGCs in disease and assess the mechanisms by which monocyte fusion contributes to the formation of MGCs. An improved understanding of the cellular origins and metabolic functions of MGCs will facilitate their identification and ultimately the treatment of diseases and disorders that involve MGCs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available