Journal
ADVANCES IN THERAPY
Volume 36, Issue 4, Pages 786-797Publisher
SPRINGER
DOI: 10.1007/s12325-019-00905-w
Keywords
Antimitotic; Haze; LASEK; MitomycinC; MMC; Ophthalmology; PRK; Refractive surgery; Surface ablation
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During the last 2 decades, modifying the shape of the cornea by means of laser photoablation has emerged as a successful and popular treatment option for refractive errors. Corneal surface ablation techniques such as photorefractive keratectomy (PRK) and laser-assisted subepithelial keratomileusis (LASEK) offer good refractive results while having a minimal impact on corneal biomechanical stability. Past limitations of these techniques included the long-term regression of refractive outcome and a vigorous healing response that reduced corneal clarity in some patients (giving rise to what is clinically described as haze). MitomycinC (MMC) was introduced as a healing modulator and applied on the corneal surface after refractive surgery to address these drawbacks. This article critically reviews the available evidence on the biological effects, safety, and clinical benefits of the off-label use of MMC in corneal refractive surgery.
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