Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 361, Issue 8, Pages 1896-1901Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201801635
Keywords
Nickel catalysis; debenzylation; regioselective; isoquinolones; 1-aminoisoquinolines
Categories
Funding
- National Natural Science Foundation of China [21572194, 21502160, 21871226]
- Collaborative Innovation Center of New Chemical Technologies for Environmental Benignity and Efficient Resource Utilization, the Hunan Provincial Innovative Foundation for Postgraduate [CX2017B301]
Ask authors/readers for more resources
An efficient method for the synthesis of substituted 1(2H)-isoquinolone derivatives via nickel-catalyzed annulation of substituted 2-halobenzamidines with aryl alkynes in the presence of water is described. Benzo[4,5]imidazo[2,1-a]isoquinolines were formed as the dominated products when dry dimethyl sulfoxide was used as the solvent. Furthermore, when benzyl substituted amidines were used as the substrates, debenzylation reaction occured to provide various 1-aminoisoquinoline products.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available