Journal
ADVANCED MATERIALS
Volume 31, Issue 18, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201807557
Keywords
blood-brain barrier penetration; central nervous system delivery; nanocapsules; nanomedicine
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Funding
- UCLA AIDS Institute HIV extinction project from the McCarthy Family Foundation
- NIH/NIAID [RO1AI110200]
- NIH/NCI [RO1CA232015]
- NIH/NIAID d [U19AI117941, R21 AI114433]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-2-001]
- National Nature Science Foundation of China [81602208]
- NIH [P30 CA016042, P30 AI028697]
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Central nervous system (CNS) diseases are the leading cause of morbidity and mortality; their treatment, however, remains constrained by the blood-brain barrier (BBB) that impedes the access of most therapeutics to the brain. A CNS delivery platform for protein therapeutics, which is achieved by encapsulating the proteins within nanocapsules that contain choline and acetylcholine analogues, is reported herein. Mediated by nicotinic acetylcholine receptors and choline transporters, such nanocapsules can effectively penetrate the BBB and deliver the therapeutics to the CNS, as demonstrated in mice and non-human primates. This universal platform, in general, enables the delivery of any protein therapeutics of interest to the brain, opening a new avenue for the treatment of CNS diseases.
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