Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 29, Issue 22, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201806883
Keywords
bioactive nanosystems; multifunctional biomaterials; tissue engineering; tumor therapy; wound healing
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Funding
- National Natural Science Foundation of China [U1501245, 51872224]
- Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University [2018LHM-KFKT004]
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The surgical procedure in skin-tumor therapy usually results in cutaneous defects, and multidrug-resistant bacterial infection could cause chronic wounds. Here, for the first time, an injectable self-healing antibacterial bioactive polypeptide-based hybrid nanosystem is developed for treating multidrug resistant infection, skin-tumor therapy, and wound healing. The multifunctional hydrogel is successfully prepared through incorporating monodispersed polydopamine functionalized bioactive glass nanoparticles (BGN@PDA) into an antibacterial F127-epsilon-Poly-L-lysine hydrogel. The nanocomposites hydrogel displays excellent self-healing and injectable ability, as well as robust antibacterial activity, especially against multidrug-resistant bacteria in vitro and in vivo. The nanocomposites hydrogel also demonstrates outstanding photothermal performance with (near-infrared laser irradiation) NIR irradiation, which could effectively kill the tumor cell (>90%) and inhibit tumor growth (inhibition rate up to 94%) in a subcutaneous skin-tumor model. In addition, the nanocomposites hydrogel effectively accelerates wound healing in vivo. These results suggest that the BGN-based nanocomposite hydrogel is a promising candidate for skin-tumor therapy, wound healing, and anti-infection. This work may offer a facile strategy to prepare multifunctional bioactive hydrogels for simultaneous tumor therapy, tissue regeneration, and anti-infection.
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