Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 29, Issue 23, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201808556
Keywords
Angstrom; anticancer; broad spectrum; low toxicity; silver particles
Categories
Funding
- Outstanding Youth Foundation of National Natural Science Foundation of China [81522012]
- National Natural Science Foundation of China [81670807, 81871822, 81801395, 81702237, 81701383, 81600699, 81802138]
- Thousand Youth Talents Plan of China [D1119003]
- Medicine and Health Science and Technology Innovation Project of Chinese Academy of Medical Sciences [2018-I2M-HL-024]
- High Level Talent Gathering Project of Hunan Province [2017XK2039, 2018RS3029]
- Innovation Driven Project of Central South University [2016CX028, 2019CX014, 2018CX029]
- Hunan Province Natural Science Foundation of China [2017JJ3501]
- China Postdoctoral Science Foundation [2017M612596, 2018M632998, 2017M622614]
- Youth Foundation of Xiangya Hospital in Central South University [2016Q10]
- Natural Science Foundation for Distinguished Yong Scholars of Guangdong Province [2016A030306051]
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Cancer incidence is rising, and the efficacy of current available anticancer agents is limited by severe dose-limiting toxicities and drug resistance problems. Nanoparticles are heralded as the next frontier in cancer treatment. Here, a pure physical method is used to efficiently fabricate very small silver particles even approaching the Angstrom (Ang) dimension. Fructose is used as a dispersant and stabilizer to coat the Ang-scale silver particles (AgAPs). Functional and mechanistic studies demonstrate that fructose-coated AgAPs (F-AgAPs) can enter and accumulate in multiple cultured cancer cell lines to induce apoptotic death, whereas most normal cells are resistant to the efficacious dose of F-AgAPs; in vivo, intravenous administration of F-AgAPs potently inhibits the growth of pancreatic and lung cancer xenografts in nude mice, without inducing notable toxic effects on the healthy tissues. The results suggest the promising potential of F-AgAPs as a potent, safe, and broad-spectrum agent for the cancer treatment.
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