Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 151, Issue -, Pages 130-151Publisher
ELSEVIER
DOI: 10.1016/j.addr.2019.01.010
Keywords
Cathepsins; Enzymes; Cancer; Drug delivery; Optical imaging
Categories
Funding
- Indo French Centre for Promotion of Advanced Research (IFCPAR/CEFIPRA)
- CSIR-New Delhi, India
- DST [EEQ/2016/000102, EMR/2016/002304]
- CNRS
- Universite Paris-Sud
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Cathepsins are an important category of enzymes that have attracted great attention for the delivery of drugs to improve the therapeutic outcome of a broad range of nanoscale drug delivery systems. These proteases can be utilized for instance through actuation of polymer-drug conjugates (e.g., triggering the drug release) to bypass limitations of many drug candidates. A substantial amount of work has been witnessed in the design and the evaluation of Cathepsin-sensitive drug delivery systems, especially based on the tetra-peptide sequence (Gly-Phe-Leu-Gly, GFLG) which has been extensively used as a spacer that can be cleaved in the presence of Cathepsin B. This Review Article will give an in-depth overview of the design and the biological evaluation of Cathepsin-sensitive drug delivery systems and their application in different pathologies including cancer before discussing Cathepsin B-cleavable prodrugs under clinical trials. (C) 2019 Elsevier B.V. All rights reserved.
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