Journal
ACTA TROPICA
Volume 191, Issue -, Pages 8-12Publisher
ELSEVIER
DOI: 10.1016/j.actatropica.2018.12.027
Keywords
Schistosoma japonicum; Glutathione S-transferase; Egg; RNA interference
Categories
Funding
- Scientific Research Subject of the Health and Family Planning Commission of Wuhan Municipality [WX17A08]
- Hubei Provincial Planning Commission Joint Fund project [WJ2018H0129]
- Hubei Provincial Natural Science Foundation project [2017CFB570]
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The aim of this study was to investigate the effect of Schistosoma japonicwn glutathione S-transferase (SjGST) on the developmental stages of the parasite. We found that the mRNA levels of GST were higher in schistosomula obtained from the host and the eggs than that in other developmental stages. SjGST was mainly distributed in the egg shells, teguments of the worms, and part of the parenchyma of the worms. GST knockdown with RNA interference in S. japonicum worms resulted in a silencing rate higher than 80%. The egg reduction rate (18%) and abnormal egg ratio (28%) were significantly higher (P < 0.05) in the GST-silenced group than in the negative control group. These results indicate that SjGST plays an important role in the fecundity of S. japonicum, specifically in egg formation.
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