Journal
ACTA BIOCHIMICA POLONICA
Volume 66, Issue 1, Pages 101-110Publisher
ACTA BIOCHIMICA POLONICA
DOI: 10.18388/abp.2018_2772
Keywords
psoriatic patients; flavonoid genistein; skin biopsy; peripheral blood cells; inflammation
Categories
Funding
- National Centre for Research and Development [NCRD - PBS1/B7/7/2012]
- National Science Centre [UMO-2017/27/B/NZ3/02212]
- Institute of Biochemistry and Biophysics of the Polish Academy of Sciences [T-32.1]
- Biofarm Sp. z o.o. from Poznan [NCRD - PBS1/B7/7/2012]
- MTZ Clinical Research from Warsaw [NCRD - PBS1/B7/7/2012]
Ask authors/readers for more resources
Despite the impressive advancements in the treatment of psoriasis over the past two decades, there is still a need for further improvement. As previously shown in the literature, genistein (5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one), naturally occurring plant compound displays multidirectional action, also in relation to alleviating psoriasis symptoms. In this work we focused our attention on genistein impact on expression of genes when treating moderate-to-severe psoriasis patients. Testing the effects of this isoflavone on transcript levels in both skin specimens and peripheral blood cells of four psoriatic subjects, we found that this compound modulated activities of genes coding for anti-psoriatic members and anti-inflammatory mediators of inflammation. It impairs the activity of certain genes which are overexpressed in psoriasis, while stimulating the expression of other transcripts that are repressed in dermatosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available