Journal
ACS NANO
Volume 13, Issue 4, Pages 4312-4321Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.8b09519
Keywords
graphene; enzyme mimic; density functional theory; biosensors; immunoassays
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2017R1A2B3004648]
- NRF - Korea government (Ministry of Science and ICT) [NRF-2017R1C1B2009460]
- NRF of Korea [NRF-2014R1A5A1009799]
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The work describes a carbon-based peroxidase mimic, N- and B-codoped reduced graphene oxide (NB-rGO), which shows high peroxidase-like activity without oxidase-like activity and has a catalytic efficiency nearly 1000-fold higher than that of undoped rGO. The high catalytic activity of NB-rGO is explained by density functional theory by calculating Gibbs free energy change during the peroxide decomposition reaction. Acetylcholine and C-reactive protein are successfully quantified with high sensitivity and selectivity, which were comparable to or better than those obtained using natural peroxidase. Furthermore, NB-rGO, which does not have oxidase-like activity, is proven to have higher sensitivity toward acetylcholine than Pt nanoparticles having oxidase-like activity. This work will facilitate studies on development, theoretical analysis for rational design, and bioassay applications of enzyme mimics based on nanomaterials.
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