Journal
ACS NANO
Volume 13, Issue 3, Pages 3095-3105Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.8b08398
Keywords
conjugated polymer; photosensitizer; two-photon; photodynamic therapy; aggregation-induced emission
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Funding
- Singapore NRF Competitive Research Program [R279-000-483-281]
- NRF Investigatorship [R279-000-444-281]
- National University of Singapore [R279-000-482-133]
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Two-photon excited photodynamic therapy (2PE-PDT) has attracted great attention in recent years due to its great potential for deep-tissue and highly spatiotemporally precise cancer therapy. Photosensitizers (PSs) with high singlet oxygen (O-1(2)) generation efficiency and large two-photon absorption (2PA) cross-sections are highly desirable, but the availability of such PSs is limited by challenges in molecular design. In this work, we report that the polymerization of small-molecule PSs with aggregation-induced emission (ME) could yield conjugated polymer PSs with good brightness, high O-1(2) generation efficiency, and large 2PA cross-sections. A pair of conjugated polymer PSs were designed and synthesized, and the corresponding ME PS dots were prepared by nanoprecipitation, which exhibited outstanding 2PE-PDT performance in in vitro cancer cell ablation and in vivo zebrafish liver tumor treatment. Our work highlights a strategy to design highly efficient PSs for 2PE-PDT.
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