Journal
ACS CHEMICAL NEUROSCIENCE
Volume 10, Issue 3, Pages 1204-1208Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.8b00540
Keywords
Parkinson's disease; alpha-synuclein; peptoid; blood-based detection; surface plasmon resonance imaging
Funding
- National Natural Science Foundation of China [31600803, 21790394, 21773042]
- Youth Innovation Promotion Association of Chinese Academy of Science [2018048]
- National Key Research and Development Program of China [2016YFF0203803]
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Parkinson's disease (PD) is a severe neurodegenerative disease and there is great need for developing a biochemical detection method to precisely diagnose it. Alpha-synuclein (alpha-syn) participates in the main pathology of PD and serves as an important biomarker of PD. Here, we identified peptoid ASBP-7 that had high affinity and specificity to a-syn by screening a peptoid library using the high-throughput surface plasmon resonance imaging method. We confirmed that ASBP-7 could significantly distinguish PD sera from the normal ones through identifying a-syn in the serum. We also demonstrated the high sensitivity of this system in detecting PD serum. This work provides a method for the blood-based, label-free, high-throughput analysis of PD serum, and holds great potential for the early diagnosis and dynamic monitoring of PD.
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