Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 11, Issue 7, Pages 6820-6828Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b21483
Keywords
rare earth; multifunctional imaging; heat shock protein; natural resources; photothermal; semiconductor
Funding
- Beijing Talent Foundation Outstanding Young Individual Project [2015000026833ZK02]
- Joint Foundation Program of Beijing Municipal Natural Science Foundation
- Beijing Municipal Education Commission [KZ201810028045]
- Capacity Building for Sci-Tech Innovation-Fundamental Scientific Research Funds [025185305000/195]
- Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan [IDHT20180517]
- Project of Construction of Scientific Research Base by the Beijing Municipal Education Commission
- Youth innovative research team of Capital Normal University
- Yanjing Young Scholar Development Program of Capital Normal University
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Multifunctional nanomaterials for dual-mode imaging guided cancer therapy are highly desirable in clinical applications. Herein, a flowerlike NiS2-coated NaLuF4:Nd (Lu:Nd@NiS2) nanoparticle was synthesized as a novel therapeutic agent for short-wave infrared light imaging and magnetic resonance imaging to guide photothermal therapy (PTT). The material was then loaded with phenolic epigallocatechin 3-gallate (EGCG), which is a natural heat-shock protein 90 (HSP90) inhibitor. Upon near infrared irradiation, EGCG was released from the Lu:Nd@NiS2-EGCG, which bound HSP90 and reduced cell tolerance to heat, resulting in a better therapeutic effect at the same elevated temperature. Therefore, with minimal side effects and remarkable antitumor efficacy in vivo, Lu:Nd@NiS2-EGCG appeared to be a promising photothermal agent for enhanced PTT.
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