Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Volume 171, Issue 6, Pages 839-847Publisher
WILEY
DOI: 10.1002/ajmg.b.32454
Keywords
PARK16; Parkinson's disease; Malaysia; genetics; meta-analysis
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Funding
- FRGS [FP017-2013]
- BNC-MSN Education [BNC-EG-006/2013]
- High-Impact Research (HIR) [UM.0000017/HIR.C3]
- National Medical Research Council
- Singapore Millennium Foundation
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PARK16 was identified as a risk factor for Parkinson's disease in a Japanese cohort; however, subsequent studies in the other populations including the Chinese, European, Caucasian, and Chilean have shown a protective role instead. To investigate this locus in our Malaysian cohort, 1,144 individuals were screened for five SNPs in the PARK16 locus and logistic regression analysis showed that the A allele of the rs947211 SNP reduced the risk of developing PD via a recessive model (Odds ratio 0.57, P-value 0.0003). Pooled analysis with other Asian studies showed that A allele of the rs947211 SNP decreased the risk of developing PD via a recessive model (Odds ratio 0.71, P-value 0.0001). In addition, when meta-analysis was performed with other Asian population, three SNPs (rs823128, rs823156, and rs11240572) reduced risk of developing PD via a dominant model. (c) 2016 Wiley Periodicals, Inc.
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