Journal
AMERICAN JOURNAL OF KIDNEY DISEASES
Volume 67, Issue 6, Pages 984-988Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ajkd.2015.12.017
Keywords
Ferumoxytol; renal failure; chronic kidney disease (CKD); magnetic resonance imaging (MRI); magnetic resonance angiography (MRA); ultra-small superparamagnetic iron oxide (USPIO); contrast agent
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Funding
- NIDDK NIH HHS [K08 DK089002] Funding Source: Medline
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Ferumoxytol is a superparamagnetic iron oxide particle encapsulated by a semisynthetic carbohydrate with properties that can be used by the nephrologist for diagnosis and therapy. Ferumoxytol is approved by the US Food and Drug Administration for treating iron deficiency anemia in the setting of chronic kidney disease, but not for clinical diagnostic imaging. It has gained appeal as a magnetic resonance imaging contrast agent in patients with estimated glomerular filtration rates < 30 mL/min/1.73 m(2) in whom gadolinium-based contrast magnetic resonance imaging agents are relatively contraindicated because of the association with gadolinium deposition and nephrogenic systemic fibrosis. Ferumoxytol metabolism is not dependent on kidney function, but rather is removed from the circulation by the reticuloendothelial system of the liver, spleen, and bone marrow. Additionally, the prolonged intravascular half-life (>14 hours) of ferumoxytol allows for longer image acquisition and repeat imaging, if necessary. In patients with contraindications for gadolinium contrast agents, ferumoxytol is an alternative agent for vascular assessment, including patency and course. (C) 2016 by the National Kidney Foundation, Inc.
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