Journal
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
Volume 60, Issue 2, Pages 181-188Publisher
WILEY-BLACKWELL
DOI: 10.1002/ajim.22675
Keywords
manganese; welding; caudate nucleus; cognitive control
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Funding
- National Institutes of Health (NIH) National Institute for Environmental Health Sciences [R01ES021488, K24ES017765, P42ES004696]
- Michael J. Fox Foundation
- NIH National Institute of Neurological Disorders and Stroke (NINDS) National Center for Research Resources (NCRR)
- NIH Roadmap for Medical Research [UL1 RR024992]
- American Parkinson Disease Association (APDA Medical Students Summer Fellowship)
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BackgroundChronic exposure to manganese (Mn) is a health concern in occupations such as welding because of well-established motor effects due to basal ganglia dysfunction. We hypothesized that cognitive control (the ability to monitor, manipulate, and regulate ongoing cognitive demands) would also be affected by chronic Mn exposure. MethodsWe examined the relationship between Mn exposure and cognitive control performance in 95 workers with varying intensity and duration (median 15.5 years) of exposure to welding fume. We performed linear regression to assess the association between exposure to Mn-containing welding fume and cognitive control tasks. ResultsOverall performance was inversely related to intensity of welding exposure (P=0.009) and was driven by the Two-Back and Letter Number Sequencing tests that assess working memory (both P=0.02). ConclusionsOccupational exposure to Mn-containing welding fume may be associated with poorer working memory performance, and workers may benefit from practices that reduce exposure intensity. Am. J. Ind. Med. 60:181-188, 2017. (c) 2016 Wiley Periodicals, Inc.
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