Journal
AMERICAN JOURNAL OF HUMAN GENETICS
Volume 98, Issue 6, Pages 1092-1100Publisher
CELL PRESS
DOI: 10.1016/j.ajhg.2016.03.025
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Funding
- Wellcome Trust as part of the Wellcome Trust Case Control Consortium 2 project [084716/Z/08/Z, 085475/B/08/Z, 085475/Z/08/Z]
- Wellcome Trust Centre for Human Genetics [090532/Z/09/Z]
- Wellcome Trust Sanger Institute Core Award [98051]
- Kenya Medical Research Institute (KEMRI)
- Wellcome Trust of Great Britain
- Wellcome Trust [084716/Z/08/Z, 090770/2/09/2, 091758, 098532, HCUZZ0]
- European Research Council
- Academy of Finland [257654]
- NIHR Biomedical Research Centre in Oxford
- Wolfson-Royal Society Merit Award
- ERC [294557]
- Wellcome Trust Career Development Fellowship [097364/Z/11/Z]
- NIHR Biomedical Research Centre in Guy's St Thomas'
- European Research Council (ERC) [294557] Funding Source: European Research Council (ERC)
- Medical Research Council [G1001712] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10019, NF-SI-0514-10158] Funding Source: researchfish
- Wellcome Trust [098532/B/12/Z] Funding Source: researchfish
- MRC [G1001712, G0901310] Funding Source: UKRI
- Wellcome Trust [084716/Z/08/Z] Funding Source: Wellcome Trust
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Bacteremia (bacterial bloodstream infection) is a major cause of illness and death in sub-Saharan Africa but little is known about the role of human genetics in susceptibility. We conducted a genome-wide association study of bacteremia susceptibility in more than 5,000 Kenyan children as part of the Wellcome Trust Case Control Consortium 2 (WTCCC2). Both the blood-culture-proven bacteremia case subjects and healthy infants as controls were recruited from Kilifi, on the east coast of Kenya. Streptococcus pneumoniae is the most common cause of bacteremia in Kilifi and was thus the focus of this study. We identified an association between polymorphisms in a long intergenic non-coding RNA (lincRNA) gene (AC011288.2) and pneumococcal bacteremia and replicated the results in the same population (p combined = 1.69 x 10(-9); OR = 2.47, 95% CI = 1.84-3.31). The susceptibility allele is African specific, derived rather than ancestral, and occurs at low frequency (2.7% in control subjects and 6.4% in case subjects). Our further studies showed AC011288.2 expression only in neutrophils, a cell type that is known to play a major role in pneumococcal clearance. Identification of this novel association will further focus research on the role of lincRNAs in human infectious disease.
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