Journal
AMERICAN JOURNAL OF EPIDEMIOLOGY
Volume 184, Issue 10, Pages 732-743Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kww080
Keywords
abdominal aortic calcification; African Americans; air pollution; atherosclerosis; carotid intima-media thickness; coronary artery calcification; peripheral artery disease; traffic pollution
Categories
Funding
- National Institute of Nursing Research [R21 NR013231]
- National Institute of Minority Health and Health Disparities
- National Heart, Lung, and Blood Institute [HHSN268201300046C, HSN268201300047C, HHSN268201300048C, HHSN268201300049C, HSN268201300050C]
- National Institute on Minority Health and Health Disparities
Ask authors/readers for more resources
To our knowledge, no study has investigated the association of long-term exposure to traffic pollution with markers of atherosclerosis in 4 vascular beds simultaneously in an all-African-American cohort. Among participants in the Jackson Heart Study (Jackson, Mississippi; baseline mean age = 55.5 (standard deviation, 12.7) years), we used linear regression to estimate percent differences in carotid intima-media thickness (CIMT) at baseline (2004) and used modified Poisson regression (robust error variance) to estimate prevalence ratios for peripheral artery disease (PAD), coronary artery calcification (CAC), and abdominal aortic calcification (AAC) at the first follow-up visit (2005-2008) for persons living less than 150m (versus more than 300 m) from major roadways, adjusting for confounders. Living less than 150m from such roadways was associated with a significant 6.67% (95% confidence interval: 1.28, 12.35) increase in CIMT (4,800 participants). PAD prevalence among persons living less than 150m from a major roadway was 1.17 (95% confidence interval: 0.73, 1.86) times that of persons living more than 300m away (4,443 participants), but this result was not statistically significant. There was no association for CAC or AAC. The association with CIMT was stronger in participants with a cardiovascular disease history than in those without one (P = 0.04). We observed an association in the carotid vascular beds but not the coronary, abdominal, or peripheral vascular beds. Our results highlight the need to consider residential proximity to roadways as a potential cardiovascular disease risk factor for blacks.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available