Journal
BIOINFORMATICS
Volume 31, Issue 19, Pages 3210-3212Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btv351
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Funding
- Swiss National Science Foundation [31003A_143936, PDFMP3_137064]
- Marie Curie International Outgoing Fellowship [PIOF-GA-2011-303312]
- Swiss National Science Foundation (SNF) [31003A_143936, PDFMP3_137064] Funding Source: Swiss National Science Foundation (SNF)
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Motivation: Genomics has revolutionized biological research, but quality assessment of the resulting assembled sequences is complicated and remains mostly limited to technical measures like N50. Results: We propose a measure for quantitative assessment of genome assembly and annotation completeness based on evolutionarily informed expectations of gene content. We implemented the assessment procedure in open-source software, with sets of Benchmarking Universal Single-Copy Orthologs, named BUSCO.
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