Journal
BIOINFORMATICS
Volume 31, Issue 18, Pages 3069-3071Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btv313
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Funding
- Cancer League of Colorado
- National Institutes of Health [P30CA046934, P50CA058187]
- David F. and Margaret T. Grohne Family Foundation
- National Research Foundation of Korea [22A20130012404] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an online DSigDB resource that allows users to search, view and download drugs/compounds and gene sets. DSigDB gene sets provide seamless integration to GSEA software for linking gene expressions with drugs/compounds for drug repurposing and translational research.
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