Journal
BIOINFORMATICS
Volume 31, Issue 10, Pages 1698-1700Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btv027
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Funding
- VIB
- University of Leuven
- Funds for Scientific Research Flanders [FWO G.0509.13]
- Flanders Institute for Science and Technology (IWT)
- Federal Office for Scientific Affairs of Belgium [Belspo IUAP P7/16]
- Fonds Wetenschappelijk Onderzoek Vlaanderen [FWOTM443]
- EMBO Short-Term Fellowship [EMBO ASTF 224-2012]
- KU Leuven
- MRC [MR/K022105/1] Funding Source: UKRI
- Medical Research Council [MR/K022105/1] Funding Source: researchfish
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Accurate prediction of amyloid-forming amino acid sequences remains an important challenge. We here present an online database that provides open access to the largest set of experimentally characterized amyloid forming hexapeptides. To this end, we expanded our previous set of 280 hexapeptides used to develop the Waltz algorithm with 89 peptides from literature review and by systematic experimental characterisation of the aggregation of 720 hexapeptides by transmission electron microscopy, dye binding and Fourier transform infrared spectroscopy. This brings the total number of experimentally characterized hexapeptides in the WALTZ-DB database to 1089, of which 244 are annotated as positive for amyloid formation.
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