Journal
BIOINFORMATICS
Volume 32, Issue 8, Pages 1244-1246Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btv723
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Funding
- Canadian Cancer Research Society
- Ontario Institute for Cancer Research
- CIHR-IG Computational Biology Undergraduate Summer Student Health Research Award
- CIBC-Brain Canada Brain Cancer Research Training Award
- Gattuso-Slaight Personalized Cancer Medicine Fund at Princess Margaret Cancer Centre
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Pharmacogenomics holds great promise for the development of biomarkers of drug response and the design of new therapeutic options, which are key challenges in precision medicine. However, such data are scattered and lack standards for efficient access and analysis, consequently preventing the realization of the full potential of pharmacogenonnics. To address these issues, we implemented PharmacoGx, an easy-to-use, open source package for integrative analysis of multiple pharnnacogenomic datasets. We demonstrate the utility of our package in comparing large drug sensitivity datasets, such as the Genomics of Drug Sensitivity in Cancer and the Cancer Cell Line Encyclopedia. Moreover, we show how to use our package to easily perform Connectivity Map analysis. With increasing availability of drug -related data, our package will open new avenues of research for meta-analysis of pharmacogenomic data.
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