Journal
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
Volume 146, Issue 3, Pages 278-288Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/AJCP/AQW110
Keywords
Gastric adenocarcinoma; T3 category; Resection; VEGF; Biomarker; Clinical outcomes
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Funding
- Youth Cultivation Program of PLA Medical Science and Technology Project [13QNP041]
- Innovation Team of Fuzhou General Hospital [2014CXTD04]
- Natural Science Foundation of Fujian Province [2012J01406]
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Objectives: To investigate the clinical and prognostic significance of high vascular endothelial growth factor (VEGF) expression in resected T3 gastric adenocarcinoma (GA). Methods: Data of VEGF expression on 453 patients with resected T3 GA were collected from a single institute in Fuzhou, China. VEGF expression in the resected tumor tissues was evaluated by immunohistochemistry (IHC). Associations between VEGF expression outcomes and prognosis were investigated using by the chi(2) test, Kaplan-Meier plus log-rank test, and univariate and multivariate Cox models. Results: In total, 48.6% (220/453) patients had low VEGF expression (IHC score <= 2+). Patients with high VEGF expression (IHC>2+; 233/453, 51.4%) had significantly poorer median recurrence-free survival time (20 vs 55 months, P < .001) and median overall survival time (28 vs 58 months; P < .001) than patients with low VEGF. High VEGF was associated with higher overall recurrence (68.2% vs 51.4%, P = 2.675 x 10(-4)), poorer overall survival (27.5% vs 47.3%, P = 1.719 x 10(-5)), and increased risk of recurrence (hazard ratio [HR], 1.71; 95% confidence interval [CI], 1.33-2.19; P = 2.43 x 10(-5)) and death (HR, 1.80; 95% CI, 1.41-2.3; P = 2.19 x 10(-6)). Conclusions: High VEGF expression is associated with a higher risk of recurrence and shorter survival in resected T3 GA. These findings may provide a foundation for evaluating VEGF-targeted molecular therapies in T3 GA.
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