4.7 Article

DisVis: quantifying and visualizing accessible interaction space of distance-restrained biomolecular complexes

Journal

BIOINFORMATICS
Volume 31, Issue 19, Pages 3222-3224

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btv333

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Funding

  1. Dutch Foundation for Scientific Research (NWO) [ECHO grant] [711.011.009]

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We present DisVis, a Python package and command line tool to calculate the reduced accessible interaction space of distance-restrained binary protein complexes, allowing for direct visualization and quantification of the information content of the distance restraints. The approach is general and can also be used as a knowledge-based distance energy term in FFT-based docking directly during the sampling stage.

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