Journal
AMERICAN JOURNAL OF CHINESE MEDICINE
Volume 44, Issue 2, Pages 197-226Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X16500130
Keywords
Carthamus tinctorius L.; Flavonoid, Hydroxysafflor Yellow A; Cardiovascular Protection; Cerebrovascular Protection; Review
Funding
- Science and Technology Development Fund, Macao S.A.R (FDCT) [074-2012-A3]
- University of Macau [MRG013-WYT-2013-ICMS, MYRG-2015-00101-ICMS-QRCM, MYRG2015-00098-ICMS-QRCM, MYRG2015-00091-ICMS-QRCM, CPG2014-00012-ICMS]
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Carthamus tinctorius L. is a multifunctional cash crop. Its flowers and seeds are extensively used in traditional herbal medicine in China, Korea, Japan, and other Asian countries, for treating various ailments such as gynecological, cardiovascular, and cerebrovascular diseases as well as blood stasis and osteoporosis. More than 100 compounds have been isolated and identified from C. tinctorius. Flavonoids and alkaloids, especially the quinochalcone C-glycoside hydroxysafflor yellow A, N-(p-Coumaroyl) serotonin, and N-feruloylserotonin, are responsible for most of the pharmacological activities of C. tinctorius. In this paper, comprehensive and up-to-date information on the phytochemistry and pharmacology of C. tinctorius is presented. This information will be helpful for further explorations of the therapeutic potential of C. tinctorius and may provide future research opportunities.
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