Journal
BIOINFORMATICS
Volume 32, Issue 5, Pages 690-696Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btv633
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Funding
- National Library of Medicine
- National Heart, Lung, and Blood Institute of the National Institutes of Health [T15LM009451, P20HL113445]
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Motivation: Current differential correlation methods are designed to determine molecular feature pairs that have the largest magnitude of difference between correlation coefficients. These methods do not easily capture molecular feature pairs that experience no correlation in one group but correlation in another, which may reflect certain types of biological interactions. We have developed a tool, the Discordant method, which categorizes the correlation types for each group to make this possible. Results: We compare the Discordant method to existing approaches using simulations and two biological datasets with different types of -omics data. In contrast to other methods, Discordant identifies phenotype-related features at a similar or higher rate while maintaining reasonable computational tractability and usability.
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