Journal
ALZHEIMERS & DEMENTIA
Volume 12, Issue 5, Pages 556-564Publisher
WILEY
DOI: 10.1016/j.jalz.2015.08.167
Keywords
Motoric cognitive risk syndrome; Mortality; Cognitive impairment; Gait speed; Dementia; Predementia syndromes
Categories
Funding
- National Institute on Aging [U01AG009740]
- NIA [U01AG032947]
- Johns Hopkins Bloomberg School of Public Health
- European Commission through 5th Framework Programme [QLK6-CT-2001-00360]
- European Commission through 6th Framework Programme [SHARE-I3, RII-CT-2006-062193]
- European Commission through the 6th Framework Programme (COMPARE) [CIT5- CT-2005-028857]
- European Commission through the 6th Framework Programme (SHARELIFE) [CIT4-CT-2006-028812]
- European Commission through 7th Framework Programme (SHARE-PREP) [211909]
- European Commission through 7th Framework Programme (SHARE-LEAP) [227822]
- European Commission through 7th Framework Programme (SHARE M4) [261982]
- U.S. National Institute on Aging [U01 AG09740-13S2, P01 AG005842, P01 AG08291, P30 AG12815, R21 AG025169, Y1-AG-4553-01, IAG BSR06-11, OGHA 04-064]
- German Ministry of Education and Research (Bundesministerium fur Bildung and Forschung, BMBF)
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Introduction: Cognitive impairment is associated with increased mortality. We examined the association between motoric cognitive risk (MCR) syndrome, a predementia syndrome characterized by slow gait and cognitive complaints, and survival. Methods: A total of 11,867 nondemented participants aged >65 years from three established cohort studies in the United States and Europe were screened for MCR. Mortality risk of MCR was assessed with Cox and logistic regression models. Results: At baseline, 836 (7.0%) participants had MCR. Over a median follow-up of 28 months, 1603 participants died (758 in first 2 years). MCR was associated with increased mortality overall (adjusted hazard ratio, 1.69; 95% confidence interval [CI], 1.46-1.96) and 2-year mortality (adjusted odds ratio, 1.89; 95% CI, 1.50-2.38). The association remained after accounting for established mortality risk factors as well as baseline gait speed and memory performance. Discussion: MCR is associated with increased mortality. Older adults should be screened for MCR to identify at-risk individuals for dementia and death. (C) 2015 Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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