Journal
ALZHEIMERS & DEMENTIA
Volume 12, Issue 3, Pages 292-323Publisher
WILEY
DOI: 10.1016/j.jalz.2016.02.002
Keywords
Alzheimer's disease; Preclinical; Asymptomatic; Diagnostic criteria; Biomarkers; Pathophysiology; Genetics; CSF biomarkers; Blood biomarkers; MRI; Amyloid PET; Tau PET
Categories
Funding
- AXA Research Fund
- Fondation Universite Pierre et Marie Curie
- Fondation pour la Recherche sur Alzheimer, Paris, France
- program Investissements d'avenir [ANR-10-IAIHU-06]
- European Medical Information Framework (EMIF)
- National Institute on Aging
- French International Foundation for Research in Alzheimer's disease (IFRAD)
- Alzheimer's Association
- ESRC [ES/L001810/1] Funding Source: UKRI
- Alzheimers Research UK [ARUK-SRF2013-8] Funding Source: researchfish
- Economic and Social Research Council [ES/L001810/1] Funding Source: researchfish
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During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at the preclinical stage before the occurrence of the first clinical symptoms. This preclinical stage of AD has become a major research focus as the field postulates that early intervention may offer the best chance of therapeutic success. To date, very little evidence is established on this silent stage of the disease. A clarification is needed about the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage. This article is aimed at addressing all the different issues by providing for each of them an updated review of the literature and evidence, with practical recommendations. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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