Journal
BIOINFORMATICS
Volume 32, Issue 2, Pages 286-288Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btv560
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Funding
- Victorian State Government Operational Infrastructure Support
- National Health and Medical Research Council [APP1051481, APP1051402]
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A Summary: DNA methylation is one of the most commonly studied epigenetic modifications due to its role in both disease and development. The Illumina HumanMethylation450 BeadChip is a cost-effective way to profile >450 000 CpGs across the human genome, making it a popular platform for profiling DNA methylation. Here we introduce missMethyl, an R package with a suite of tools for performing normalization, removal of unwanted variation in differential methylation analysis, differential variability testing and gene set analysis for the 450K array.
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