Journal
ALLERGY
Volume 71, Issue 7, Pages 1057-1061Publisher
WILEY-BLACKWELL
DOI: 10.1111/all.12889
Keywords
allergen immunotherapy; clinical effect; house dust mite; immunological response; local allergic rhinitis
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Funding
- Instituto de Salud Carlos III - Fondo Europeo de Desarrollo Regional-FEDER (network RIRAAF) [RD07/0064, FIS PI11/02619, PI12/00900]
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The effects of allergen immunotherapy (AIT) on local allergic rhinitis (LAR) are largely unknown. We conducted the first randomized, double-blind, placebo-controlled (DBPC), phase II trial of D. pteronyssinus (DP) subcutaneous AIT (DP-AIT) on LAR (clinicaltrials. gov identifier: NCT02123316). Thirty-six LAR patients received Pangramin PLUS DP or placebo for 24 months. The primary endpoints were symptoms, medication scores, and medication-free days. The secondary included skin test, serum specific IgE and IgG4, nasal allergen provocation test (NAPT), and adverse events. AIT-DP produced significant improvements in both primary and secondary endpoints vs placebo. After 12 months of AIT-DP, we detected a significant and marked increase in allergen tolerance with negative NAPT in 50% of patients, and significant increases of serum sIgG4. Immunotherapy was well tolerated; no systemic reactions were reported. This study demonstrated that AIT-DP is a safe and clinically effective treatment for LAR, confirming that LAR is a new indication for AIT.
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