Journal
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Volume 43, Issue 7, Pages 790-801Publisher
WILEY
DOI: 10.1111/apt.13552
Keywords
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Funding
- Falk
- Abbvie
- Joel Pekow
- NIH
- American Cancer Society
- Takeda
- Abvie
- Exact Sciences Corporation
- National Institute of Health [NIDDK 1K01DK094986-01]
- Chemotherapy Foundation
- Helmsley Foundation
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BackgroundLittle is known about the role of the microbiome in primary sclerosing cholangitis. AimTo explore the mucosa-associated microbiota in primary sclerosing cholangitis (PSC) patients across different locations in the gut, and to compare it with inflammatory bowel disease (IBD)-only patients and healthy controls. MethodsBiopsies from the terminal ileum, right colon, and left colon were collected from patients and healthy controls undergoing colonoscopy. Microbiota profiling using bacterial 16S rRNA sequencing was performed on all biopsies. ResultsForty-four patients were recruited: 20 with PSC (19 with PSC-IBD and one with PSC-only), 15 with IBD-only and nine healthy controls. The overall microbiome profile was similar throughout different locations in the gut. No differences in the global microbiome profile were found. However, we observed significant PSC-associated enrichment in Barnesiellaceae at the family level, and in Blautia and an unidentified Barnesiellaceae at the genus level. At the operational taxa unit level, most shifts in PSC were observed in Clostridiales and Bacteroidales orders, with approximately 86% of shifts occurring within the former order. ConclusionsThe overall microbiota profile was similar across multiple locations in the gut from the same individual regardless of disease status. In this study, the mucosa associated-microbiota of patients with primary sclerosing cholangitis was characterised by enrichment of Blautia and Barnesiellaceae and by major shifts in operational taxa units within Clostridiales order.
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