Journal
ALCOHOL AND ALCOHOLISM
Volume 52, Issue 1, Pages 1-4Publisher
OXFORD UNIV PRESS
DOI: 10.1093/alcalc/agw068
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Funding
- Fondecyt [1130012, 1150589]
- Millennium Institute [P09-015-F]
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Study describes the blockade of relapse-like alcohol drinking by mesenchymal stem cells (MSCs). High alcohol-intake bred rats consumed alcohol for 3 months and were subjected to repeated alcohol deprivations for 7-14 days, followed by alcohol reaccess. Upon reaccess, animals consumed 2.2 g alcohol/kg in 60 minutes. A single intra-cerebroventricular MSC administration inhibited relapse-like drinking up to 80-85% for 40 days (P < 0.001). An alcohol-use-disorder was prevented.
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