Journal
BIOESSAYS
Volume 37, Issue 10, Pages 1139-1148Publisher
WILEY
DOI: 10.1002/bies.201500063
Keywords
3D culture; Alzheimer's disease; APP; human stem cell; presenelin
Categories
Funding
- Cure Alzheimer's fund
- Bio & Medical Technology Development Program of the National Research Foundation - Korean government, MSIP [2015M3A9C7030151]
- National Institute of Health [1RF1AG048080-01, 5P01AG15379, 2R01AG014713, 5R37MH060009]
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Alzheimer's disease (AD) is the most common cause of dementia, and there is currently no cure. The beta-amyloid cascade hypothesis of AD is the basis of current understanding of AD pathogenesis and drug discovery. However, no AD models have fully validated this hypothesis. We recently developed a human stem cell culture model of AD by cultivating genetically modified human neural stem cells in a three-dimensional (3D) cell culture system. These cells were able to recapitulate key events of AD pathology including beta-amyloid plaques and neurofibrillary tangles. In this review, we will discuss the progress and current limitations of AD mouse models and human stem cell models as well as explore the breakthroughs of 3D cell culture systems. We will also share our perspective on the potential of dish models of neurodegenerative diseases for studying pathogenic cascades and therapeutic drug discovery.
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