Journal
BIOESSAYS
Volume 37, Issue 8, Pages 867-876Publisher
WILEY
DOI: 10.1002/bies.201500013
Keywords
fission; fusion; mitochondrial dynamics; mitochondrial quality control; mitohormesis; mitophagy; ROS
Categories
Funding
- Rembrandt Institute for Cardiovascular Science
- ERC [638290]
- VENI grant from ZonMw [91613050]
Ask authors/readers for more resources
Mitochondrial function is key for maintaining cellular health, while mitochondrial failure is associated with various pathologies, including inherited metabolic disorders and age-related diseases. In order to maintain mitochondrial quality, several pathways of mitochondrial quality control have evolved. These systems monitor mitochondrial integrity through antioxidants, DNA repair systems, and chaperones and proteases involved in the mitochondrial unfolded protein response. Additional regulation of mitochondrial function involves dynamic exchange of components through mitochondrial fusion and fission. Sustained stress induces a selective autophagy - termed mitophagy - and ultimately leads to apoptosis. Together, these systems form a network that acts on the molecular, organellar, and cellular level. In this review, we highlight how these systems are regulated in an integrated context- and time-dependent network of mitochondrial quality control that is implicated in healthy aging.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available