Journal
AGING CELL
Volume 15, Issue 3, Pages 400-406Publisher
WILEY
DOI: 10.1111/acel.12455
Keywords
cellular senescence; chronic and autoimmune diseases; immune cells; tissue homeostasis
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Funding
- IMTO-Vieillissement-Fond d'Amorcage
- Inserm
- European Union project Innovative Medicine Initiative ('BeTheCure') [115142-2]
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Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and specialized cells from various tissues of all ages, invitro and invivo. Here, we review recent findings on the role of cellular senescence in immune cell fate decisions in macrophage polarization, natural killer cell phenotype, and following T-lymphocyte activation. We also introduce the involvement of the onset of cellular senescence in some immune responses including T-helper lymphocyte-dependent tissue homeostatic functions and T-regulatory cell-dependent suppressive mechanisms. Altogether, these data propose that cellularsenescence plays a wide-reaching role as a homeostatic orchestrator.
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