Journal
AGING CELL
Volume 15, Issue 6, Pages 999-1017Publisher
WILEY
DOI: 10.1111/acel.12518
Keywords
cellular senescence; cell stress; DNA damage; DNA replication stress; epigenetic modifiers; aging
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Funding
- Russian Science Foundation [14-24-00022]
- Russian Science Foundation [14-24-00022] Funding Source: Russian Science Foundation
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To date, dozens of stress-induced cellular senescence phenotypes have been reported. These cellular senescence states may differ substantially from each other, as well as from replicative senescence through the presence of specific senescence features. Here, we attempted to catalog virtually all of the cellular senescence-like states that can be induced by low molecular weight compounds. We summarized biological markers, molecular pathways involved in senescence establishment, and specific traits of cellular senescence states induced by more than fifty small molecule compounds.
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