Journal
AGEING RESEARCH REVIEWS
Volume 32, Issue -, Pages 150-168Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2016.02.009
Keywords
Lysosomal cell death; Cathepsin; Lysosomes; Lysosomal membrane permeabilization; Autophagy; Lipids; Aging
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Funding
- MINECO Consolider [CSD2010-00045, SAF2012-36079, SAF2014-57539-R]
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Lysosomes are degradative organelles essential for cell homeostasis that regulate a variety of processes, from calcium signaling and nutrient responses to autophagic degradation of intracellular components. Lysosomal cell death is mediated by the lethal effects of cathepsins, which are released into the cytoplasm following lysosomal damage. This process of lysosomal membrane permeabilization and cathepsin release is observed in several physiopathological conditions and plays a role in tissue remodeling, the immune response to intracellular pathogens and neurodegenerative diseases. Many evidences indicate that aging strongly influences lysosomal activity by altering the physical and chemical properties of these organelles, rendering them more sensitive to stress. In this review we focus on how aging alters lysosomal function and increases cell sensitivity to lysosomal membrane permeabilization and lysosomal cell death, both in physiological conditions and age-related pathologies. (C) 2016 Elsevier B.V. All rights reserved.
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