Journal
AGEING RESEARCH REVIEWS
Volume 26, Issue -, Pages 96-111Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2016.01.007
Keywords
Cardiovascular; Falls; Disability; Cognition; Blood pressure; Antihypertensive
Categories
Funding
- American Heart Association [13SDG17080033]
- National Institutes of Health [2P30AG028740]
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Hypertension is a highly prevalent condition with numerous health risks, and the incidence of hypertension is greatest among older adults. Traditional discussions of hypertension have largely focused on the risks for cardiovascular disease and associated events. However, there are a number of collateral effects, including risks for dementia, physical disability, and falls/fractures which are increasingly garnering attention in the hypertension literature. Several key mechanisms - including inflammation, oxidative stress, and endothelial dysfunction - are common to biologic aging and hypertension development and appear to have key mechanistic roles in the development of the cardiovascular and collateral risks of late-life hypertension. The objective of the present review is to highlight the multi-dimensional risks of hypertension among older adults and discuss potential strategies for treatment and future areas of research for improving overall care for older adults with hypertension. (C) 2016 Elsevier B.V. All rights reserved.
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