Journal
AGEING RESEARCH REVIEWS
Volume 26, Issue -, Pages 72-80Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2015.12.007
Keywords
Aging; Vestibular system; Neuropathology; Mitochondria; Mammals; Therapy
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Funding
- Federal Ministry for Education and Research [01EO0901]
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Dizziness and imbalance frequently affect the elderly and contribute to falls and frailty. In many geriatric patients, clinical testing uncovers a dysfunction of the vestibular system, but no specific etiology can be identified. Neuropathological studies have demonstrated age-related degeneration of peripheral and central vestibular neurons, but the molecular mechanisms are poorly understood. In contrast, recent studies into age-related hearing loss strongly implicate mitochondria! dysfunction, oxidative stress and apoptotic cell death of cochlear hair cells. While some data suggest that analogous biological pathomechanisms may underlie vestibular dysfunction, actual proof is missing. In this review, we summarize the available data on the molecular causes of vestibular dysfunction. (C) 2016 Elsevier B.V. All rights reserved.
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