Journal
AGE AND AGEING
Volume 45, Issue 2, Pages 209-216Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ageing/afv192
Keywords
sarcopenia; grip strength; international; systematic review; old people
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Funding
- MRC [MC_U147585819, MC_UU_12019/1, MC_UU_12019/4, MC_U147585827, MC_UU_12011/2, MC_UP_A620_1015] Funding Source: UKRI
- Medical Research Council [MC_U147585819, MC_UP_A620_1014, MC_UU_12019/1, MC_U147585827, MC_U147585824, MC_UU_12019/4, MC_UP_A620_1015, U1475000001, MC_UU_12011/2, MC_UU_12011/1, U1475000002] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10085, CL-2015-26-004, NF-SI-0508-10082] Funding Source: researchfish
- Medical Research Council [MC_UU_12019/1, MC_UU_12019/4, MC_U147585819, MC_UU_12011/1, MC_UP_A620_1015, MC_U147585824, MC_UU_12011/2, MC_UP_A620_1014, MC_U147585827] Funding Source: Medline
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Methods: we searched MEDLINE and EMBASE for reporting age- and gender-stratified normative data for grip strength. We extracted each item of normative data and converted it on to a Z-score scale relative to our British centiles. We performed meta-regression to pool the Z-scores and compare them by world region. Findings: our search returned 806 abstracts. Sixty papers met inclusion criteria and reported on 63 different samples. Seven UN regions were represented, although most samples (n = 44) were based in developed regions. We extracted 726 normative data items relating to 96,537 grip strength observations. Normative data from developed regions were broadly similar to our British centiles, with a pooled Z-score 0.12 SDs (95% CI: 0.07, 0.17) above the corresponding British centiles. By comparison, normative data from developing regions were clearly lower, with a pooled Z-score of -0.85 SDs (95% CI: -0.94, -0.76). Interpretation: our findings support the use of our British grip strength centiles and their associated cut points in consensus definitions for sarcopenia and frailty across developed regions, but highlight the need for different cut points in developing regions.
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