Journal
AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES
Volume 13, Issue 4, Pages 210-215Publisher
AFRICAN NETWORKS ETHNOMEDICINES
DOI: 10.21010/ajtcam.v13i4.27
Keywords
Kaempferol; Breast Cancer; Apoptosis
Categories
Ask authors/readers for more resources
Background: Kaempferol, a natural flavonoid, has been shown to induce cancer cell apoptosis and cell growth inhibition in several tumors. Previously we have conducted a full investigation on the chemical constituents of Gynura medica, kaempferol and its glycosides are the major constituents of G. medica. Here we investigated the growth inhibition and apoptosis induction effect of kaempferol extracted from G. medica. Materials and Methods: The inhibition effects of kaempferol were evaluated by MTS assay and soft agar colony formation assay. Fluorescence staining and western blotting were be used to study the apoptosis. The structure was identified by H-1- NMR), C-13- NMR and ESI-MS analyses. Results: Our results showed that kaempferol's inhibition of MCF-7 breast cancer cell growth may through inducing apoptosis and downregulation of Bcl2 expression. Conclusion: Kaempferol is a promising cancer preventive and therapeutic agent for breast cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available