Journal
BIOELECTROCHEMISTRY
Volume 105, Issue -, Pages 16-24Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.bioelechem.2015.04.006
Keywords
Alternating electric field; Hyperthermia; Chemotherapeutic adjuvant; Pancreatic tumor; TTFields
Funding
- Spanish government [AR00311 - MICINN-TEC2010-11182-E, SAF2012-33636, RTICCC RD12/0036/0031]
- European Commission [IRG 256376]
- Generalitat de Catalunya [2009 SGR 1356]
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Delivery of the so-called Tumor Treatment Fields (TTFields) has been proposed as a cancer therapy. These are low magnitude alternating electric fields at frequencies from 100 to 300 kHz which are applied continuously in a non-invasive manner. Electric field delivery may produce an increase in temperature which cannot be neglected. We hypothesized that the reported results obtained by applying TTFields in vivo could be due to heat rather than to electrical forces as previously suggested. Here, an in vivo study is presented in which pancreatic tumors subcutaneously implanted in nude mice were treated for a week either with mild hyperthermia (41 degrees C) or with TTFields (6 V/cm, 150 kHz) and tumor growth was assessed. Although the TTFields applied singly did not produce any significant effect, the combination with chemotherapy did show a delay in tumor growth in comparison to animals treated only with chemotherapy (median relative reduction = 47%). We conclude that concomitant chemotherapy and TTFields delivery show a beneficial impact on pancreatic tumor growth. Contrary to our hypothesis, this impact is non-related with the induced temperature increase. (C) 2015 Elsevier B.V. All rights reserved.
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