Journal
ADVANCES IN COLLOID AND INTERFACE SCIENCE
Volume 228, Issue -, Pages 17-39Publisher
ELSEVIER
DOI: 10.1016/j.cis.2015.11.007
Keywords
Amino acid-based surfactants; Antimicrobial activity; Mode of action; Aggregation; Cytotoxicity
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The rapid increase of drug resistant bacteria makes necessary the development of new antimicrobial agents. Synthetic amino acid-based surfactants constitute a promising alternative to conventional antimicrobial compounds given that they can be prepared from renewable raw materials. In this review, we discuss the structural features that promote antimicrobial activity of amino acid-based surfactants. Monocatenary, dicatenary and gemini surfactants that contain different amino acids on the polar head and show activity against bacteria are revised. The synthesis and basic physico-chemical properties have also been included. (C) 2015 Elsevier B.V. All rights reserved.
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